CD Markers

Topic Completed: 1 February 2002

Minor changes: 9 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD80[title]

Nat Pernick, M.D.
Page views in 2020: 217
Page views in 2021 to date: 4
Cite this page: Pernick N. CD80. website. Accessed January 16th, 2021.
Definition / general
  • Also called B7-1, BB1
  • T cells need two signals for activation; the first signal is antigen peptide presented on MHC class II through the T cell receptor
  • The second (costimulatory) signal is delivered by CD80 or CD86, expressed on surface of antigen presenting cells, which interact with either CD28 or CD152 (CTLA-4)
  • Has critical role in autoimmune, humoral and transplant responses
  • Increased expression may cause excessive antigen presentation in fulminant hepatic failure, as an early step in its pathogenesis before the onset of tissue damage (Am J Pathol 1999;154:1711)
  • Receptor for some adenovirus species (Virus Res 2006;122:144)
  • References: OMIM #112203
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Activated B cells, T cells, macrophages and dendritic cells
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