CD Markers
CD80
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD80[title]
CD80
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD80[title]
Cite this page: Pernick N. CD80. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd80.html. Accessed January 16th, 2021.
Definition / general
- Also called B7-1, BB1
- T cells need two signals for activation; the first signal is antigen peptide presented on MHC class II through the T cell receptor
- The second (costimulatory) signal is delivered by CD80 or CD86, expressed on surface of antigen presenting cells, which interact with either CD28 or CD152 (CTLA-4)
- Has critical role in autoimmune, humoral and transplant responses
- Increased expression may cause excessive antigen presentation in fulminant hepatic failure, as an early step in its pathogenesis before the onset of tissue damage (Am J Pathol 1999;154:1711)
- Receptor for some adenovirus species (Virus Res 2006;122:144)
- References: OMIM #112203
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Activated B cells, T cells, macrophages and dendritic cells
