CD Markers

Topic Completed: 1 February 2002

Minor changes: 9 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD81[title]

Nat Pernick, M.D.
Page views in 2020: 534
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Cite this page: Pernick N. CD81. website. Accessed January 15th, 2021.
Definition / general
  • Also called Target of an Anti-Proliferative Antibody (TAPA1)
  • Receptor for Hepatitis C Virus E2 protein in B cells (J Virol 2006;80:8695)
  • Also required for Plasmodium falciparum infectivity (Nat Med 2003;9:93)
  • Upregulation on HIV1+ B cells may ultimately cause lymphoproliferative disorders (Clin Exp Immunol 2007;147:53)
  • On B cells, is complexed with CD21, CD19 and Leu13; facilitates complement recognition
  • Member of tetraspanin family; has close associations with major histocompatibility complex class I/II proteins
  • Appears to promote muscle cell fusion and support myotube maintenance
  • References: OMIM #186845
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Lymphocytes, endothelial cells and epithelial cells
Positive staining - tumors
Negative staining
  • Erythrocytes, platelets and neutrophils
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