CD Markers
CD81
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD81[title]
CD81
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD81[title]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - tumors | Negative stainingCite this page: Pernick N. CD81. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd81.html. Accessed January 15th, 2021.
Definition / general
- Also called Target of an Anti-Proliferative Antibody (TAPA1)
- Receptor for Hepatitis C Virus E2 protein in B cells (J Virol 2006;80:8695)
- Also required for Plasmodium falciparum infectivity (Nat Med 2003;9:93)
- Upregulation on HIV1+ B cells may ultimately cause lymphoproliferative disorders (Clin Exp Immunol 2007;147:53)
- On B cells, is complexed with CD21, CD19 and Leu13; facilitates complement recognition
- Member of tetraspanin family; has close associations with major histocompatibility complex class I/II proteins
- Appears to promote muscle cell fusion and support myotube maintenance
- References: OMIM #186845
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Lymphocytes, endothelial cells and epithelial cells
Positive staining - tumors
- HCV+ splenic diffuse large B cell lymphoma (Hum Pathol 2005;36:878)
- Burkitt’s lymphoma cell lines, neuroblastoma cell lines (J Pediatr Hematol Oncol 2000;22:20)
Negative staining
- Erythrocytes, platelets and neutrophils
