CD Markers
CD82
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD82[title]
CD82
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD82[title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Negative stainingCite this page: Pernick N. CD82. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd82.html. Accessed April 15th, 2021.
Definition / general
- Also called prostate cancer antimetastasis gene KAI1, kangai 1 (Chinese for anticancer)
- Metastasis suppressor gene
- Expression correlates with p53 expression
- Reduced expression of CD82 is associated with metastases / poor prognosis in carcinomas of bladder (Int J Urol 2004;11:74), breast (Am J Pathol 1998;153:973, J Cancer Res Clin Oncol 2005;131:191), colon (World J Gastroenterol 2004;10:2245), endometrium (Clin Cancer Res 2003;9:1393), larynx (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2005;19:1065), oral cavity (Clin Cancer Res 2002;8:828) and thyroid (Int J Mol Med 2004;14:517, Pathol Res Pract 2003;199:79)
- Expression reduces function of urokinase-type plasminogen activator receptor (J Biol Chem 2005;280:14811)
- References: OMIM #600623
Uses by pathologists
- Possible use as prognostic marker (see above)
Microscopic (histologic) images
Images hosted on other servers:
Endometrial carcinoma
Oral cavity (normal and malignant)
Breast carcinoma (D-F)
Positive staining - normal
- Activated / differentiated hematopoietic cells, endothelial cells and epithelium
Negative staining
- Erythrocytes
