CD Markers
CD83
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD83[title]
CD83
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD83[title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. CD83. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd83.html. Accessed January 15th, 2021.
Definition / general
- Also called HB15
- May assist in antigen presentation or cellular interactions that follow lymphocyte activation
- Soluble form inhibits dendritic cell maturation and inhibits dendritic cell-mediated T cell proliferation (J Med Dent Sci 2006;53:85)
- Elevated serum levels seen in mantle cell lymphoma and CLL (Leuk Res 2004;28:237)
- Higher number of activated dendritic cells may be good prognostic factor for breast carcinoma (Int J Cancer 2003;104:92), cholangiocarcinoma (Hum Pathol 2004;35:881), colorectal liver metastases (Hum Pathol 2004;35:1392), gallbladder carcinoma (Oncol Rep 2005;14:353), gastric carcinoma-EBV+ (Am J Surg Pathol 2006;30:59) and advanced (Oncol Rep 2005;14:369)
- References: OMIM #604534
Uses by pathologists
- Marker for activated dendritic cells
Microscopic (histologic) images
Images hosted on other servers:
Infantile hemangioma endothelium
Decidua
CD83+ dendritic cells in breast tumor
Positive staining - normal
- Activated (mature) dendritic cells, activated T and B lymphocytes, monocytes / macrophages (transient, Biochem J 2005;385:85), Langerhans cells, thymic epithelial cells, neutrophils during acute bacterial infection (Clin Exp Immunol 2002;130:501) and decidua (Am J Pathol 2000;157:159)
Positive staining - disease
- Infantile hemangioma endothelium (Am J Pathol 2006;168:621), Reed-Sternberg cells (Pathology 1997;29:294) and Churg-Strauss syndrome myocarditis in inflammatory infiltrates (Arch Pathol Lab Med 2003;127:98)
