CD Markers

Topic Completed: 1 February 2002

Minor changes: 9 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD86[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD86. website. Accessed January 16th, 2021.
Definition / general
  • Also called B7-2
  • T cells need two signals for activation - the first signal is antigen peptide presented on MHC class II through the T cell receptor
  • The second (costimulatory) signal is delivered by CD80 or CD86, expressed on surface of antigen presenting cells, which interact with either CD28 or CD152 (CTLA-4)
  • CD80 and CD86 appear to have opposing functions on regulatory T cells (J Immunol 2004;172:2778)
  • Polymorphisms are associated with liver transplant acceptance (Transpl Immunol 2005;15:69) and systemic sclerosis (Int J Immunogenet 2006;33:155)
  • Increased expression may cause excessive antigen presentation in fulminant hepatic failure as an early step in its pathogenesis before the onset of tissue damage (Am J Pathol 1999;154:1711)
  • High circulating soluble levels are poor prognostic factor in myeloma (Br J Haematol 2006;133:165); are associated with severe asthma (Thorax 2004;59:870)
  • Receptor for some adenovirus species (Virus Res 2006;122:144)
  • Associated with H. pylori dependent early stage high grade MALT lymphoma of stomach (World J Gastroenterol 2005;11:4357)
Uses by pathologists
  • No significant clinical use by pathologists
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
Positive staining - normal
  • Interdigitating dendritic cells in T zones of secondary lymphoid organs, Langerhans cells, peripheral blood dendritic cells, memory B cells, germinal center B cells, monocytes, endothelial cells, activated T cells
Positive staining - disease
Negative staining
  • Immature dendritic cells
Additional references
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