CD Markers
CD86
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD86[title]
CD86
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD86[title]
Table of Contents
Definition / general | Uses by pathologists | Uses by pathologists | Positive staining - normal | Positive staining - normal | Positive staining - disease | Negative staining | Additional referencesCite this page: Pernick N. CD86. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd86.html. Accessed January 16th, 2021.
Definition / general
- Also called B7-2
- T cells need two signals for activation - the first signal is antigen peptide presented on MHC class II through the T cell receptor
- The second (costimulatory) signal is delivered by CD80 or CD86, expressed on surface of antigen presenting cells, which interact with either CD28 or CD152 (CTLA-4)
- CD80 and CD86 appear to have opposing functions on regulatory T cells (J Immunol 2004;172:2778)
- Polymorphisms are associated with liver transplant acceptance (Transpl Immunol 2005;15:69) and systemic sclerosis (Int J Immunogenet 2006;33:155)
- Increased expression may cause excessive antigen presentation in fulminant hepatic failure as an early step in its pathogenesis before the onset of tissue damage (Am J Pathol 1999;154:1711)
- High circulating soluble levels are poor prognostic factor in myeloma (Br J Haematol 2006;133:165); are associated with severe asthma (Thorax 2004;59:870)
- Receptor for some adenovirus species (Virus Res 2006;122:144)
- Associated with H. pylori dependent early stage high grade MALT lymphoma of stomach (World J Gastroenterol 2005;11:4357)
Uses by pathologists
- No significant clinical use by pathologists
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- B cells, thymocytes (J Immunol 2001;167:3668), mature T cells, memory T cells (high, Tissue Antigens 2004;64:132), monocytes / macrophages, platelets, dendritic cells, granulocytes and CD34+ hematopoietic progenitor cells (Exp Hematol 2003;31:798)
Positive staining - normal
- Interdigitating dendritic cells in T zones of secondary lymphoid organs, Langerhans cells, peripheral blood dendritic cells, memory B cells, germinal center B cells, monocytes, endothelial cells, activated T cells
Positive staining - disease
- AML (29%, Clin Cancer Res 2005;11:5708), ulcerative colitis (100%, Dig Dis Sci 2004;49:1738)
Negative staining
- Immature dendritic cells
Additional references
