CD Markers
CD89
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD89
CD89
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 9 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD89
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Negative staining | Additional referencesCite this page: Pernick N. CD89. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd89.html. Accessed January 15th, 2021.
Definition / general
- Also called FCAR, FCalphaR
- IgA Fc receptor, binds IgA and eliminates IgA coated targets
- Induces phagocytosis, degranulation, respiratory burst and killing of microorganisms
- Pathogenic group A and group B streptococci produce virulence factors that block the binding of IgA to CD89, inhibiting IgA-mediated immunity (J Biol Chem 2006;281:1389)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Neutrophils, monocytes/macrophages, activated eosinophils, alveolar and splenic macrophages, interstitial dendritic cells
Negative staining
- Mesangial cells (J Am Soc Nephrol 2000;11:241)
Additional references
