CD Markers

Topic Completed: 1 September 2013

Minor changes: 9 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CD91[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD91. website. Accessed January 15th, 2021.
Definition / general
  • Low density lipoprotein receptor-related protein 1 (LRP1); also called alpha-2-macroglobulin receptor
  • Large scavenger receptor that mediates the uptake and degradation of various ligands
  • Binds to apoE-containing lipoproteins and mediates chylomicron remnant clearance from the plasma
  • May suppress thyroid carcinoma invasion by clearing urokinase plasminogen activator (Int J Biochem Cell Biol 2006;38:1729)
  • Increased CD91 surface expression on CD14(+) monocytes is associated with the apparent HIV1 resistance observed in HIV exposed but seronegative subjects (J Leukoc Biol 2005;78:37)
  • Increased expression on monocytes in melanoma patients is associated with slow progression (Clin Exp Immunol 2004;138:312)
  • Part of pathway of C1q-mediated apoptotic clearance (Arthritis Rheum 2006;54:1543)
  • Also a cell surface receptor for heat shock protein gp96 and others (Arch Pathol Lab Med 2003;127:178)
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
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