CD Markers
CD91
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD91[title]
CD91
Author: Nat Pernick, M.D.
Topic Completed: 1 September 2013
Minor changes: 9 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD91[title]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Additional referencesCite this page: Pernick N. CD91. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd91.html. Accessed January 15th, 2021.
Definition / general
- Low density lipoprotein receptor-related protein 1 (LRP1); also called alpha-2-macroglobulin receptor
- Large scavenger receptor that mediates the uptake and degradation of various ligands
- Binds to apoE-containing lipoproteins and mediates chylomicron remnant clearance from the plasma
- May suppress thyroid carcinoma invasion by clearing urokinase plasminogen activator (Int J Biochem Cell Biol 2006;38:1729)
- Increased CD91 surface expression on CD14(+) monocytes is associated with the apparent HIV1 resistance observed in HIV exposed but seronegative subjects (J Leukoc Biol 2005;78:37)
- Increased expression on monocytes in melanoma patients is associated with slow progression (Clin Exp Immunol 2004;138:312)
- Part of pathway of C1q-mediated apoptotic clearance (Arthritis Rheum 2006;54:1543)
- Also a cell surface receptor for heat shock protein gp96 and others (Arch Pathol Lab Med 2003;127:178)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Fibroblasts, dendritic cells (Immunobiology 2006;211:407), macrophages; liver, brain, lung
Additional references
