CD Markers
CD97


Topic Completed: 1 September 2013

Minor changes: 9 October 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: CD97

Nat Pernick, M.D.
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Cite this page: Pernick N. CD97. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd97.html. Accessed January 15th, 2021.
Definition / general
  • Binds to CD55 and G protein-coupled receptors
  • May be involved in cell adhesion and signaling processes early after leukocyte activation
  • May be involved in migration of neutrophils (J Immunol 2004;172:1125)
  • Highly expressed at sites of inflammation in skin, lung and rheumatoid arthritis
  • May contribute to angiogenesis associated with tumors (Blood 2005;105:2836)
  • Glycosylation causes CD97 to show two different epitopes, EGF and Stalk (Int J Cancer 2004;112:815)
Uses by pathologists
  • No significant clinical use by pathologists
Microscopic (histologic) images

Images hosted on other servers:
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Normal oral mucosa

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Gastric carcinoma

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Oral squamous cell carcinoma

Positive staining - normal
  • Activated T > B cells, monocytes / macrophages, dendritic cells, granulocytes, smooth muscle cells
Positive staining - disease
Negative staining
  • Microglia
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