Other tumors

Epithelioid trophoblastic tumor

Topic Completed: 1 May 2007

Minor changes: 3 September 2021

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed Search: Epithelioid trophoblastic tumor cervix

Branko Perunovic, D.M.
Page views in 2020: 383
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Cite this page: Perunovic B. Epithelioid trophoblastic tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixETT.html. Accessed November 29th, 2021.
Definition / general
  • Rare tumor (100 cases reported) in women of reproductive age with abnormal vaginal bleeding
  • Associated with a gestational event, mean 6 years prior
  • Usually elevated serum hCG
  • In uterine fundus, lower uterine segment or endocervix
  • Neoplastic counterpart to placental site nodule, with malignant intermediate trophoblast
  • Metastases in 25%, death in 10%; similar behavior as placental site trophoblastic tumor; less aggressive than choriocarcinoma
Case reports
Microscopic (histologic) description
  • Resembles placental site trophoblastic tumor
  • Invasive nodules of monomorphic intermediate sized intermediate trophoblast cells with abundant eosinophilic or clear cytoplasm, medium / large irregular nuclei with distinct nucleoli; occasional multinucleated cells
  • Tumor cells surround extensive necrosis and hyaline - like matrix
  • 2+ mitotic figures/10 HPF
  • At periphery, tumors infiltrate normal tissue in small round nests or cords, including focal replacement of surface or glandular epithelium with stratified neoplastic cells
  • Often decidualized stroma nearby
  • Usually no definite SIL
Negative stains
Differential diagnosis
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