Table of Contents
Terminology | Etiology | Clinical features | Cytology description | Cytology images | Differential diagnosisCite this page: Rosa M. HSIL / CIN III (cyto). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixcytologyHSILCINIII.html. Accessed February 27th, 2021.
Terminology
- Also called carcinoma in situ
Etiology
- Due to high risk HPV infection
Clinical features
- Cases with only a few abnormal cells are more likely to be missed (Arch Pathol Lab Med 2004;128:746))
- Underdiagnosis may be due to air drying artifact and metaplasia (Indian J Cancer 2004;41:104)
- Cases diagnosed antepartum usually persist postpartum, and 11% develop invasive carcinoma postpartum (Cancer 2004;102:228)
Cytology description
- Usually single, small, round / oval cells with scant cytoplasm and increased N/C ratio (greater than 1/2)
- Nuclear membrane does not have sharp angles
- Nuclei vary markedly in contour and have irregular coarsely clumped chromatin
- No macronucleoli, no tumor diathesis
Cytology images
Differential diagnosis