Cervix
Premalignant / preinvasive lesions - cytology
HSIL / CIN III (cyto)
Author: Marilin Rosa, M.D.
Topic Completed: 1 June 2011
Minor changes: 5 July 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed search: HSIL CIN III severe dysplasia
Table of Contents
Terminology | Etiology | Clinical features | Cytology description | Cytology images | Differential diagnosisCite this page: Rosa M. HSIL / CIN III (cyto). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixcytologyHSILCINIII.html. Accessed June 23rd, 2021.
Terminology
- Also called carcinoma in situ
Etiology
- Due to high risk HPV infection
Clinical features
- Cases with only a few abnormal cells are more likely to be missed (Arch Pathol Lab Med 2004;128:746))
- Underdiagnosis may be due to air drying artifact and metaplasia (Indian J Cancer 2004;41:104)
- Cases diagnosed antepartum usually persist postpartum, and 11% develop invasive carcinoma postpartum (Cancer 2004;102:228)
Cytology description
- Usually single, small, round / oval cells with scant cytoplasm and increased N/C ratio (greater than 1/2)
- Nuclear membrane does not have sharp angles
- Nuclei vary markedly in contour and have irregular coarsely clumped chromatin
- No macronucleoli, no tumor diathesis
Cytology images
Images hosted on other servers:
Parabasal cells with nuclear enlargement
HSIL in pregnant patient
HSIL, suspicious for invasion
HSIL and LSIL
Differential diagnosis
