Premalignant / preinvasive lesions - cytology

HSIL / CIN III (cyto)

Topic Completed: 1 June 2011

Minor changes: 5 July 2020

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PubMed search: HSIL CIN III severe dysplasia

Marilin Rosa, M.D.
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Cite this page: Rosa M. HSIL / CIN III (cyto). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixcytologyHSILCINIII.html. Accessed September 22nd, 2021.
  • Also called carcinoma in situ
  • Due to high risk HPV infection
Clinical features
Cytology description
  • Usually single, small, round / oval cells with scant cytoplasm and increased N/C ratio (greater than 1/2)
  • Nuclear membrane does not have sharp angles
  • Nuclei vary markedly in contour and have irregular coarsely clumped chromatin
  • No macronucleoli, no tumor diathesis
Cytology images

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Parabasal cells with nuclear enlargement

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HSIL in pregnant patient

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HSIL, suspicious for invasion

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Differential diagnosis
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