Cytologic features
Small blue cells

Topic Completed: 1 March 2011

Minor changes: 20 November 2020

Copyright: 2006-2021, PathologyOutlines.com, Inc.

PubMed search: small blue cells cervix

Farnaz Hasteh, M.D.
Page views in 2020: 1,130
Page views in 2021 to date: 312
Cite this page: Hasteh F. Small blue cells. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixcytologysmallbluecell.html. Accessed March 9th, 2021.
Definition / general
  • Associated with tamoxifen therapy (present in 40% of Pap smears of patients with tamoxifen therapy) and atrophy
  • Not associated with malignancy
  • May represent reserve cells of cervical / vaginal epithelium (Arch Pathol Lab Med 2001; 125:1047)
Microscopic (histologic) description
  • Tight clusters of undifferentiated small cells with minimal cytoplasm or naked nuclei, round to oval nuclei, bland chromatin, indistinct nucleoli
Differential diagnosis
Back to top
Image 01 Image 02