Cervix
Squamous cell carcinoma
Verrucous carcinoma
Topic Completed: 1 August 2015
Minor changes: 30 November 2020
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PubMed Search: Verrucous carcinoma [title] cervix
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Cite this page: Sunassee A. Verrucous carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixcytologyverrucousca.html. Accessed January 16th, 2021.
Clinical features
Vaginal bleeding
Exophytic tumorous massRadiology description
Ultrasonography with color
Doppler:
- Hyperechogenic mass with honeycomb appearance and hypervascularization of the tumor
MRI:
- Homogenous intensity on T1 weighted images
- Heterogenous intensity on T2 weighted images
After administration of contrast medium, tumor exhibits lower signal intensity than surrounding cervical stroma (J Reprod Med 2007;52:441)
Treatment
Usually surgical excision
Radiation may induce anaplastic transformation with subsequent regional and distal metastasis
Further surgical excision (even exenteration) is required for recurrent tumors (Zhonghua Yi Xue Za Zhi (Taipei) 2000;63:765) Gross description
Large, exophytic, warty lesion resembling condyloma
Cut surface shows sharply circumscribed deep margin Microscopic (histologic) description
Thickened, acanthotic papillary squamous epithelium with mild dysplasia and diffuse parakeratosis
Fibrovascular cores limited to superficial part of tumor (in contrast to benign condyloma, where fibrovascular cores extend from a deep layer to the surface)
Well differentiated bulbous rete ridge pattern at the base of the lesion (helps to distinguish from a well differentiated squamous carcinoma, that forms keratin superficially but may be relatively anaplastic and infiltrating in deeper layers)
Blunt pattern of invasion, with minimal nuclear atypia at epithelial-stromal interface
May be exophytic and endophytic
May have intense inflammatory infiltrate
No / rare mitotic figures
(Anticancer Res 2007;27:4491, Ann Diagn Pathol 2009;13:344) Microscopic (histologic) images
AFIP images
Squamous cells with central keratinization
Bland epithelium with at most mild atypia
Pushing margin
Images hosted on other servers:
Various images
Molecular / cytogenetics description

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