Benign / nonneoplastic epithelial lesions

Diffuse laminar endocervical hyperplasia

Topic Completed: 1 May 2007

Minor changes: 18 February 2021

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed Search: Diffuse laminar endocervical glandular hyperplasia cervix

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Diffuse laminar endocervical hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixdiffuselaminar.html. Accessed October 28th, 2021.
Definition / general
  • Also called nonspecific hyperplasia
  • Usually an incidental finding
  • First described in 1991 (Am J Surg Pathol 1991;15:1123)
  • Mean age 37 years, range 22 to 48 years
  • Nonneoplastic, incidental finding, no recurrences after surgery
Case reports
Microscopic (histologic) description
  • Diffuse proliferation of medium sized, evenly spaced, closely packed, well differentiated mucinous glands within inner third of cervical wall
  • Area sharply demarcated from underlying storm
  • Cells have basal nuclei
  • Associated with chronic inflammation and stromal edema
  • No significant cytologic atypic
  • No mitotic activity, no / rare apoptotic activity (Int J Gynecol Pathol 2002;21:125), not deeply invasive
Negative stains
Differential diagnosis
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