Premalignant / preinvasive lesions - H&E

Endocervical glandular atypia / dysplasia

Last author update: 1 May 2007
Last staff update: 16 November 2020

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PubMed search: Endocervical glandular atypia cervix

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Endocervical glandular atypia / dysplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixendocervglandatypia.html. Accessed August 13th, 2022.
Definition / general
  • More severe cases are called endocervical glandular dysplasia (atypical hyperplasia)
  • In United Kingdom, use terminology of CGIN - cervical glandular intraepithelial neoplasia
  • Not a reproducibly defined entity with a specific cause or outcome
  • Patients with diagnosis based on cervicovaginal smears often have squamous dysplasia (Obstet Gynecol 1992;79:101)
  • Appears to NOT be a precursor to adenocarcinoma in situ (Hum Pathol 2000;31:656)
  • Atypical oxyphilic metaplasia: incidental finding of endocervical glands lined by large cuboidal or polygonal epithelial cells with dense, eosinophilic, focally vacuolated cytoplasm and variable nuclear enlargement, hyperchromatism, multiple lobes or multinucleation; no mitotic activity or stratification; benign behavior (Int J Gynecol Pathol 1997;16:99)
Microscopic (histologic) description
Glandular atypia
  • Glandular cells with hyperchromatic nuclei with only occasional mitotic figures and minimal pseudostratification
  • No cribriform areas, no papillary projections, no crowding, no mitotic figures
  • Alternatively there is marked atypia involving only a single gland
  • Normal N/C ratio
Glandular dysplasia
  • Resembles adenocarcinoma in situ but nuclei are not malignant and have fewer mitotic figures OR malignant involvement of only one gland
Microscopic (histologic) images

AFIP images

Reactive glandular atypia

Glandular dysplasia

Cytology description
Positive stains
Negative stains
  • HPV (usually)
Differential diagnosis
Additional references
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