Cervix

Premalignant / preinvasive lesions - H&E

Endocervical glandular atypia / dysplasia

Author: Branko Perunovic, D.M.

Topic Completed: 1 May 2007

Minor changes: 16 November 2020

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed search: Endocervical glandular atypia cervix

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Table of Contents

Cite this page: Perunovic B. Endocervical glandular atypia / dysplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixendocervglandatypia.html. Accessed December 3rd, 2021.

Definition / general

More severe cases are called endocervical glandular dysplasia (atypical hyperplasia)
In United Kingdom, use terminology of CGIN - cervical glandular intraepithelial neoplasia
Not a reproducibly defined entity with a specific cause or outcome
Patients with diagnosis based on cervicovaginal smears often have squamous dysplasia (Obstet Gynecol 1992;79:101)
Appears to NOT be a precursor to adenocarcinoma in situ (Hum Pathol 2000;31:656)
Atypical oxyphilic metaplasia: incidental finding of endocervical glands lined by large cuboidal or polygonal epithelial cells with dense, eosinophilic, focally vacuolated cytoplasm and variable nuclear enlargement, hyperchromatism, multiple lobes or multinucleation; no mitotic activity or stratification; benign behavior (Int J Gynecol Pathol 1997;16:99)

Microscopic (histologic) description

Glandular atypia

Glandular cells with hyperchromatic nuclei with only occasional mitotic figures and minimal pseudostratification
No cribriform areas, no papillary projections, no crowding, no mitotic figures
Alternatively there is marked atypia involving only a single gland
Normal N/C ratio

Glandular dysplasia