Cervix
Premalignant / preinvasive lesions - H&E
Endocervical glandular atypia / dysplasia
Author: Branko Perunovic, D.M.
Topic Completed: 1 May 2007
Minor changes: 16 November 2020
Copyright: 2007-2021, PathologyOutlines.com, Inc.
PubMed search: Endocervical glandular atypia cervix
Table of Contents
Definition / general | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Perunovic B. Endocervical glandular atypia / dysplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixendocervglandatypia.html. Accessed June 20th, 2021.
Definition / general
- More severe cases are called endocervical glandular dysplasia (atypical hyperplasia)
- In United Kingdom, use terminology of CGIN - cervical glandular intraepithelial neoplasia
- Not a reproducibly defined entity with a specific cause or outcome
- Patients with diagnosis based on cervicovaginal smears often have squamous dysplasia (Obstet Gynecol 1992;79:101)
- Appears to NOT be a precursor to adenocarcinoma in situ (Hum Pathol 2000;31:656)
- Atypical oxyphilic metaplasia: incidental finding of endocervical glands lined by large cuboidal or polygonal epithelial cells with dense, eosinophilic, focally vacuolated cytoplasm and variable nuclear enlargement, hyperchromatism, multiple lobes or multinucleation; no mitotic activity or stratification; benign behavior (Int J Gynecol Pathol 1997;16:99)
Microscopic (histologic) description
Glandular atypia
- Glandular cells with hyperchromatic nuclei with only occasional mitotic figures and minimal pseudostratification
- No cribriform areas, no papillary projections, no crowding, no mitotic figures
- Alternatively there is marked atypia involving only a single gland
- Normal N/C ratio
- Resembles adenocarcinoma in situ but nuclei are not malignant and have fewer mitotic figures OR malignant involvement of only one gland
Microscopic (histologic) images
AFIP images
Reactive glandular atypia
Glandular dysplasia
Cytology description
Positive stains
- p16 (in dysplasia, Hum Pathol 2004;35:689, but not atypia or reactive lesions, Am J Surg Pathol 2003;27:187)
Negative stains
- HPV (usually)
Differential diagnosis
- Arias-Stella reaction
- Inflammation
- Microglandular hyperplasia
- Metaplasia
- Radiation
- Tamoxifen or oral contraceptives
Additional references
