Other tumors


Last author update: 1 May 2007
Last staff update: 18 February 2021

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PubMed Search: Lymphoma cervix

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Lymphoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixlymphoma.html. Accessed July 5th, 2022.
Definition / general
  • Primaries are rare in cervix (< 100 cases reported)
Clinical features
  • Mean age approximately 40 years; range 20's to 80's
  • Usually presents with abnormal uterine or vaginal bleeding
  • Cervical smear may be first indication of tumor but smear is often negative or reported as SIL
  • Most cases present with stage IE disease (Am J Obstet Gynecol 2005;193:866)
  • Usually diffuse large B cell lymphoma or follicular lymphoma (Mod Pathol 2000;13:19)
  • 5 year survival: 83% in low stage tumors, 29% in high stage tumors
  • Should confirm with immunostains to rule out other unusual tumors and to classify
Case reports
Gross description
  • Diffuse enlargement of cervix (barrel shaped), or polypoid mass with fish flesh appearance
  • Soft, gray white
Microscopic (histologic) description
  • Tumor cells infiltrate stroma without destroying glandular or squamous epithelium
Cytology description
Cytology images

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Differential diagnosis
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