Cervix
Benign / nonneoplastic epithelial lesions
Mesonephric rests / remnants
Author: Branko Perunovic, D.M.
Topic Completed: 1 May 2007
Minor changes: 30 November 2020
Copyright: 2007-2021, PathologyOutlines.com, Inc.
PubMed Search: Mesonephric rests
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Perunovic B. Mesonephric rests / remnants. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixmesonephricrest.html. Accessed May 12th, 2021.
Definition / general
- Remnants of mesonephric (Wolffian) ducts which form the epididymis and vas deferens in males, present in 1/3 of women
- Unrelated to symptoms that cause excision of tissue; usually no clinical mass (Am J Surg Pathol 1990;14:1100)
- Mesonephric adenocarcinoma is a rare varient of cervical adenocarcinoma that arises from mesonephric rests deep in the cervical stroma
Case reports
- Patients with squamous cell carcinoma (Am J Surg Pathol 1994;18:1265, Cesk Patol 2004;40:109)
- Patient with atypical mesonephric rests associated with cervical osteosarcoma (Cancer 1988;62:1594)
Microscopic (histologic) description
- Dilated tubules of cuboidal cells with eosinophilic secretions, surrounded by endocervical stroma
- May undergo atypical hyperplastic changes or malignant change
Microscopic (histologic) images
AFIP images
Clusters of mesonephric
tubules surround a
branching duct
Mesonephric remnants with hyaline secretion
Cells are cuboidal
with a distinct basement
membrane
Complex and deep
duct with focal
squamous metaplasia
Cytology description
- May cause abnormal pap smears (Int J Gynecol Pathol 2003;22:121)
Positive stains
- CD10, PAX2 (Am J Surg Pathol 2010;34:137), bcl2, CD10 (usually)
- p16 weak (Gynecol Oncol 2010;116:468), vimentin
Negative stains
- CEA, p53, Ki67, mucicarmine, PAS
Differential diagnosis
- Adenocarcinoma: involves overlying endocervical mucosa, invasive, has stromal response and cytologic atypia, no lobular pattern, no intraluminal eosinophilic material
Additional references
