Benign / nonneoplastic epithelial lesions

Mesonephric rests / remnants

Topic Completed: 1 May 2007

Minor changes: 30 November 2020

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed Search: Mesonephric rests

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Mesonephric rests / remnants. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixmesonephricrest.html. Accessed December 6th, 2021.
Definition / general
  • Remnants of mesonephric (Wolffian) ducts which form the epididymis and vas deferens in males, present in 1/3 of women
  • Unrelated to symptoms that cause excision of tissue; usually no clinical mass (Am J Surg Pathol 1990;14:1100)
  • Mesonephric adenocarcinoma is a rare varient of cervical adenocarcinoma that arises from mesonephric rests deep in the cervical stroma
Case reports
Microscopic (histologic) description
  • Dilated tubules of cuboidal cells with eosinophilic secretions, surrounded by endocervical stroma
  • May undergo atypical hyperplastic changes or malignant change
Microscopic (histologic) images

AFIP images

Clusters of mesonephric
tubules surround a
branching duct

Mesonephric remnants with hyaline secretion

Cells are cuboidal
with a distinct basement

Complex and deep
duct with focal
squamous metaplasia

Cytology description
Negative stains
Differential diagnosis
  • Adenocarcinoma: involves overlying endocervical mucosa, invasive, has stromal response and cytologic atypia, no lobular pattern, no intraluminal eosinophilic material
Additional references
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