Cervix
Mesenchymal / mixed epithelial & mesenchymal tumors
Myofibroblastoma
Author: Branko Perunovic, D.M.
Topic Completed: 1 May 2007
Minor changes: 11 March 2020
Copyright: 2007-2021, PathologyOutlines.com, Inc.
PubMed Search: Myofibroblastoma cervix[title}
Table of Contents
Definition / general | Gross description | Microscopic (histologic) description | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Perunovic B. Myofibroblastoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixmyofibroblastoma.html. Accessed March 9th, 2021.
Definition / general
- Mean age 55 - 58 years, range 23 - 80 years
- Often vaginal or vulvar, may be cervical
- Benign behavior but may recur after excision
- May be neoplastic proliferation of hormonally responsive mesenchymal cells native to subepithelial stroma of endocervix and vulva of adult women
Gross description
- Well circumscribed, polypoid or nodular mass, mean 3 cm (range 1 to 6 cm) arising in the superficial lamina propria of cervix and vagina
Microscopic (histologic) description
- Well circumscribed cellular tumor composed of bland spindled and stellate mesenchymal cells in collagenous stroma with myxoid and edematous foci
- Often lacelike pattern in hypocellular area, vague fascicular growth pattern in cellular area
- Minimal mitotic activity
- No atypical mitotic figures
Positive stains
- Vimentin, ER, PR, desmin, CD34, CD99, bcl2, calponin
- Alpha smooth muscle actin (45%), muscle specific actin (25%)
Negative stains
- S100, EMA, keratin, h-caldesmon, CD117
Differential diagnosis
Additional references
