Benign / nonneoplastic epithelial lesions
Nabothian cysts

Topic Completed: 1 May 2007

Minor changes: 23 May 2020

Copyright: 2007-2020, PathologyOutlines.com, Inc.

PubMed Search: Nabothian cysts cervix

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Nabothian cysts. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixnabothiancyst.html. Accessed September 18th, 2020.
Definition / general
  • A normal finding; no treatment needed
  • Due to obstruction of crypt openings containing mucus by squamous epithelium, causing acute and chronic cervicitis; also form after subtotal hysterectomy due to ablation of cervical canal (J Reprod Med 1999;44:567)
  • Associated with endocervical tunnel clusters (Am J Surg Pathol 1990;14:895)
  • Deep cysts may resemble malignancy by imaging studies
Gross description
  • Single or multiple, up to 1.5 cm
Gross images

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Nabothian follicles (chronic cervicitis)

Microscopic (histologic) description
  • Uniform architecture
  • Dilated mucin filled cyst lined by flattened mucinous epithelium without atypia
  • May rupture with extravasation of mucin into stroma and reactive changes
  • May penetrate deep into wall
  • No stratification, no mitotic figures
Microscopic (histologic) images

Contributed by Andrey Bychkov, M.D., Ph.D.

Endocervical polyp with Nabothian cysts

Positive stains
Differential diagnosis
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