Benign / nonneoplastic epithelial lesions

Pagetoid dyskeratosis

Topic Completed: 1 May 2007

Minor changes: 12 March 2020

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed Search: Pagetoid dyskeratosis

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Pagetoid dyskeratosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixpagetoid.html. Accessed December 2nd, 2021.
Definition / general
  • Reactive process in which some keratinocytes are induced to proliferate
  • Also found in intertriginous areas - may be due to friction
  • In cervix, associated with uterine prolapse (Am J Surg Pathol 2000;24:1518)
Microscopic (histologic) description
  • Small numbers of large cells with central pyknotic nuclei, perinuclear halos and abundant cytoplasm
  • No mucin
  • Resembles Paget disease
Molecular / cytogenetics description
  • Negative for HPV
Differential diagnosis
  • Artifact: signet ring morphology with eccentric pyknotic nuclei
  • Extramammary Paget disease
  • Glycogen-rich cells: large, vacuolated, pale-staining squamous cells with regular nuclei and "basket-weave" pattern
  • Koilocytes: large cells with perinuclear clearing, cytoplasmic margination giving sharp edge to halo; large, irregular, hyperchromatic nuclei, often with binucleation; usually in midzone of superficial layer
  • Pagetoid spread of carcinoma
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