Benign / nonneoplastic epithelial lesions

Placental site nodule

Topic Completed: 1 May 2007

Minor changes: 30 November 2020

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed Search: Placental site nodule

Branko Perunovic, D.M.
Page views in 2020: 408
Page views in 2021 to date: 458
Cite this page: Perunovic B. Placental site nodule. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixplacentalsitenod.html. Accessed December 3rd, 2021.
Definition / general
Gross description
  • May be visible but usually small
  • Single or multiple
Microscopic (histologic) description
  • Resembles trophoblasts in chorion lava
  • Well defined hyalinized lesion, variably cellular, immediately below mucosa, composed of extravillous (intermediate) trophoblast cells with abundant amphophilic, glycogen rich or eosinophilic cytoplasm with vacuoles, irregular nuclei with degenerative features and possible atypic
  • Occasional inflammatory cells, rare / no mitotic figures
Microscopic (histologic) images

AFIP images

Nodule just below surface
with sparsely
cellular stroma

Cytoplasmic vacuoles
and nuclear

Negative stains
  • Ki67 ( < 8% positivity)
Differential diagnosis
Additional references
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