Cervix
Mesenchymal / mixed epithelial & mesenchymal tumors
Rhabdomyosarcoma


Topic Completed: 1 May 2007

Minor changes: 22 February 2021

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed Search: Rhabdomyosarcoma cervix [title]

Branko Perunovic, D.M.
Page views in 2020: 1,724
Page views in 2021 to date: 378
Cite this page: Perunovic B. Rhabdomyosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixrhabdomyosarcoma.html. Accessed February 27th, 2021.
Definition / general
  • Rhabdomyosarcomas are divided into embryonal, botryoid (subtype of embryonal), alveolar or pleomorphic (anaplastic) subtypes
  • Embryonal type is most common; occurs in children; more common in vagina than cervix
  • Cases in older women often contain cartilage and have better prognosis
Case reports
Embryonal rhabdomyosarcoma:

Other types:
Treatment
Gross description
  • Botryoid cases have protrusion of grape-like masses (due to edema and myxoid stroma) from cervix into vagina
  • Surface is glistening and translucent
Gross images

Images hosted on other servers:
Missing Image

Embryonal rhabdomyosarcoma

Microscopic (histologic) description
  • Botryoid - polypoid mass of rhabdomyoblasts at different maturational stages covered by attenuated epithelium; resembles vaginal tumor; often cambium layer beneath cervical epithelium in botryoid cases; often loose myxoid stroma, surface ulceration; may have cartilage in older women; variable mitotic rate
  • In young children, tumor cells may lack marked atypia and may blend in with normal, immature, cellular stroma
Microscopic (histologic) images

AFIP images

Cambian layer and edematous stroma

Edematous stroma

Cytology description
  • Loose clusters of spindled cells in a necrotic background; cells have mild nuclear atypia, thin nuclear membrane, fine chromatin pattern, partly clear nucleolus
Positive stains
Differential diagnosis
  • Adenosarcoma: fibrous stroma so no grape-like clusters, no edematous, leaf-like pattern resembling phyllodes tumor
  • Edematous mesodermal polyp: adult women, small, soft fleshy protuberances up to 1.5 cm, stroma is uniform, no cambium layer, no rhabdomyoblasts, may have widely scattered atypical stromal cells
  • Yolk sac tumor
Back to top
Image 01 Image 02