Squamous cell carcinoma

Warty (condylomatous) carcinoma

Topic Completed: 1 May 2007

Minor changes: 20 February 2020

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed Search: Warty (condylomatous) carcinoma cervix

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Warty (condylomatous) carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixwartycarcinoma.html. Accessed December 3rd, 2021.
Definition / general
  • Very rare variant of invasive squamous cell carcinoma; more common in vulva
  • May be less aggressive than well differentiated squamous carcinoma
Gross description
Microscopic (histologic) description
  • Striking condylomatous or warty appearance, although deep margin is similar to classic squamous cell carcinoma
  • Often koilocytotic atypia
Cytology description
  • Liquid based cytology: small, cohesive clusters and syncytial sheets of tumor cells with vague papillary architecture; tumor cells are polygonal or elongated with oval nuclei, coarse chromatin, occasionally distinct nucleoli; also many koilocytes, some with marked nuclear atypia due to pleomorphic nuclei and distinct nuclei; dyskeratotic tumor cells with bizarre shapes; background has dispersed malignant squamous cells and tumor diathesis (Acta Cytol 2003;47:159)
Molecular / cytogenetics description
  • HPV+ (often different HPVs)
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