CNS tumor

Meningeal tumors

Chordoid meningioma

Topic Completed: 1 January 2015

Minor changes: 23 February 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Chordoid meningioma [title]

Jesse L. Kresak, M.D.
Anthony T. Yachnis, M.D.
Page views in 2020: 4,625
Page views in 2021 to date: 5,119
Cite this page: Kresak J, Yachnis A. Chordoid meningioma. website. Accessed December 8th, 2021.
Definition / general
  • WHO grade II due to tendency to recur
  • < 1% of all meningiomas
  • Usually adults (mean age 47 years) with no systemic symptoms
  • Cases in young adults / pediatric population may be associated with hematologic conditions, such as Castleman disease
  • 80% are supratentorial but also infratentorial, intraventricular, in spinal cord and optic nerve
Radiology images

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Enlarged residual tumor

Prognostic factors
Case reports
  • Gross total resection when possible
  • Postoperative radiation often added for subtotal resections
Gross description
  • Dural based
  • Well circumscribed
Microscopic (histologic) description
  • Called "chordoid" because it resembles a chordoma, with cords or trabeculae of epithelioid cells that may be eosinophilic or clear (resembling physaliferous cells) within a mucin rich or myxoid stroma
  • Often traditional meningioma features are intermixed
  • Contains a variable lymphoplasmacytic infiltrate
Cytology description
  • Cords of polygonal tumor cells with bland nuclei and nuclear pseudoinclusions
  • Occasional loose cells with abundant metachromatic pink purple cells without cytoplasmic vacuoles
  • Also lymphoplasmacytic infiltrate (Acta Cytol 2004;48:259, Acta Cytol 2004;48:397)
Cytology images

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Vacuolated cells

Positive stains
Negative stains
Differential diagnosis
Additional references
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