CNS tumor
Meningeal tumors
Clear cell meningioma

Topic Completed: 1 March 2015

Minor changes: 12 December 2019

Revised: 2 January 2019, last major update March 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Clear cell meningioma [title]

Jesse L. Kresak, M.D.
Anthony T. Yachnis, M.D.
Page views in 2019: 3,326
Page views in 2020 to date: 1,386
Cite this page: Kresak J. Clear cell meningioma. website. Accessed May 27th, 2020.
Definition / general
  • Rare variant, 0.2 - 0.8% of all meningiomas (J Neurooncol 2007;81:315)
  • WHO grade II due to aggressiveness
  • 20 - 60% chance of recurrence even with gross total resection
  • More common in younger patients (mean age 29 years)
  • Predilection for cauda equina and cerebellopontine areas
  • Predilection for CP angle and cauda equina
Radiology description
  • Indistinguishable from classic meningioma
  • Dural based, homogenously enhancing
Radiology images

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Various images

Case reports
  • Gross total resection
  • Postsurgical radiation
Microscopic (histologic) description
  • Patternless arrangement of clear cells with sometimes distinct cell borders
  • Prominent perivascular and interstitial collagen
  • Little to no mitotic activity
  • May not display any characteristic meningioma features (whorls, psamomma bodies, intranuclear inclusions)
Microscopic (histologic) images

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Clear cells with fibrous areas

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Clear cells

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Extensive vacuolation

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Monotonous round cells

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Cytology description
  • Whorled, syncytial architecture composed of spindle to polygonal cells with vacuolated cytoplasm and bland nuclei (Diagn Cytopathol 1998;18:131)
Positive stains
Negative stains
Electron microscopy description
  • Abundant cytoplasmic glycogen
  • Intermediate filaments
  • Interdigitation of cell membranes, desmosomes
  • Occasional cytoplasmic lumina (Ultrastruct Pathol 1999;23:51)
Differential diagnosis
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