CNS tumor
Diffuse astrocytic and oligodendroglial tumors
Diffuse astrocytoma, NOS
Author: Eman Abdelzaher, M.D., Ph.D.
Editorial Board Member: Maria Martinez-Lage, M.D.
Deputy Editor-in-Chief: Debra L. Zynger, M.D.
Topic Completed: 1 February 2018
Minor changes: 31 August 2020
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PubMed Search: Diffuse astrocytoma NOS
Cite this page: Abdelzaher E. Diffuse astrocytoma, NOS. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumordiffuseastrocytomaNOS.html. Accessed December 2nd, 2021.
Definition / general
- See also Diffuse astrocytoma, IDH-mutant, Diffuse astrocytic and oligodendroglial tumors-General
- Tumor morphologically conforming with diffuse astrocytoma but in which IDH testing is not available or cannot be fully performed
- Modifier "not otherwise specified" (NOS) does not refer to a specific entity; it simply indicates that the case requires additional molecular workup (Acta Neuropathol 2016;131:803)
- Full IDH evaluation requires IDH sequencing for IDH1 codon 132 and IDH2 codon 172 mutations following a negative IDH1-R132H immunohistochemistry (Acta Neuropathol 2016;131:803)
Microscopic (histologic) images
Contributed by Eman Abdelzaher, M.D., Ph.D.
Diffuse astrocytoma, NOS: low power
Diffuse astrocytoma, NOS: medium power
Subpial accumulation
Diffuse astrocytoma, NOS: high power
Perineuronal satellitosis
Perivascular accumulation
