CNS tumor
Diffuse astrocytoma-gemistocytic
Author: Eman Abdelzaher, M.D., Ph.D.
Topic Completed: 1 February 2012
Minor changes: 8 July 2020
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Diffuse astrocytoma (gemistocytic [title])
Table of Contents
Definition / general | Case reports | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Differential diagnosisCite this page: Abdelzaher, E. Diffuse astrocytoma-gemistocytic. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumordiffusegemistocytic.html. Accessed January 23rd, 2021.
Definition / general
- Variant in which gemistocytes constitute > 20% of tumor cells
Case reports
- Congenital brain tumor (University of Pittsburgh: Congenital Brain Tumor)
Gross images
Images hosted on other servers:
Frontal lobe tumor
Microscopic (histologic) description
- Infiltrative tumor with gemistocytes, characterized by ample eosinophilic glassy cytoplasm and eccentric nuclei with frequent prominent nucleoli
- Background is coarse fibrillary; perivascular lymphocyte cuffing is common
Microscopic (histologic) images
Images hosted on other servers:
Astrocytes with abundant eosinophilic cytoplasm
GFAP
Vimentin
Differential diagnosis
- Gliosis: hypertrophy of cells rather than hyperplasia, even distribution
- Ganglioglioma: neoplastic neurons
- Subependymal giant cell tumor: intraventricular, larger nuclei, noninfiltrative
