CNS tumor
Diffuse astrocytoma-gemistocytic

Topic Completed: 1 February 2012

Minor changes: 8 July 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Diffuse astrocytoma (gemistocytic [title])

Eman Abdelzaher, M.D., Ph.D.
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Cite this page: Abdelzaher, E. Diffuse astrocytoma-gemistocytic. website. Accessed January 23rd, 2021.
Definition / general
  • Variant in which gemistocytes constitute > 20% of tumor cells
Case reports
Gross images

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Frontal lobe tumor

Microscopic (histologic) description
  • Infiltrative tumor with gemistocytes, characterized by ample eosinophilic glassy cytoplasm and eccentric nuclei with frequent prominent nucleoli
  • Background is coarse fibrillary; perivascular lymphocyte cuffing is common
Microscopic (histologic) images

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Astrocytes with abundant eosinophilic cytoplasm



Positive stains
Differential diagnosis
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