CNS tumor
Glioependymal / ependymal cyst

Topic Completed: 1 February 2012

Minor changes: 27 July 2020

Copyright: (c) 2002-2020,, Inc.

PubMed Search: "Ependymal cyst"

Eman Abdelzaher, M.D., Ph.D.
Page views in 2019: 1,551
Page views in 2020 to date: 928
Cite this page: Abdelzaher E. Glioependymal / ependymal cyst. website. Accessed August 7th, 2020.
Definition / general
  • Rare, benign intraparenchymal and often paraventricular cyst lined by simple epithelium or glial tissue, S100+ or GFAP+, resting on neuroglia (J Neuroradiol 1995;22:48)
  • Usually intracranial, not midline but may affect spinal cord; may affect adult cerebellum or represent burned out pilocytic astrocytoma
  • Not in communication with ventricle or CSF spaces
  • Rarely ruptures and causes meningitis
  • Cyst lined by glial tissue
Radiology images

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MR: cystic lesion of right frontal lobe

Case reports
Gross description
  • Resembles arachnoid cyst
Gross images

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Ependymal cyst

Microscopic (histologic) description
  • Simple columnar or cuboidal cells, often ciliated, resting on neuroglia; no fibrous capsule
  • Alternatively, wall lined by gliosis, Rosenthal fibers present, variable hemosiderin; no epithelial lining
Microscopic (histologic) images

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Collapsed cystic structure consisting
of thin fibrous wall lined by
flattened to cuboidal ependymal
cells with focal multilayering

Positive stains
Negative stains
Electron microscopy description
  • Neuroepithelial origin
Differential diagnosis
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