CNS & pituitary tumors

Gliomas, glioneuronal tumors, and neuronal tumors

Neuronal and mixed neuronal-glial tumors

Extraventricular neurocytoma

Last author update: 1 January 2006
Last staff update: 1 September 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Extraventricular neurocytoma [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Extraventricular neurocytoma. website. Accessed March 30th, 2023.
Definition / general
Radiology description
  • Circumscribed, solitary and 57% cystic
Prognostic factors
  • Poor prognostic factors: incomplete excision, atypical features, high cell proliferation rates; also older patient age
Case reports
  • Total excision prevents recurrence
Microscopic (histologic) description
  • Sheets, clusters, ribbons or rosettes of monotonous tumor cells with round and regular vesicular nuclei and distinct nucleoli embedded in matrix of fine neuropil
  • Ganglion cells in 66%
  • Atypical if necrosis, vascular proliferation and 3+ mitotic figures/10 HPF
Positive stains
  • Synaptophysin (strong), GFAP (46%; also is staining of entrapped astrocytes at periphery)
Electron microscopy description
  • Neuritic type processes with microtubules, dense core granules
Differential diagnosis
  • Ependymoma
  • Oligodendroglioma: no ganglion cell differentiation, no salt and pepper chromatin and no neuropil islands; usually more infiltrative, synaptophysin-
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