CNS tumor

Diffuse astrocytic and oligodendroglial tumors

Glioblastoma-giant cell



Topic Completed: 1 March 2012

Minor changes: 25 September 2020

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PubMed Search: Giant cell glioblastoma [title]

Eman Abdelzaher, M.D., Ph.D.
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Cite this page: Abdelzaher E. Glioblastoma-giant cell. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumorglioblastomagiantcell.html. Accessed November 27th, 2021.
Definition / general
  • 5% of glioblastomas
  • Also affects younger individuals
  • May have better prognosis than classic glioblastoma
  • WHO grade IV
Radiology description
  • May mimic a metastasis
Case reports
Gross description
  • Circumscribed, firm, often subcortical mass
Gross images

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Well circumscribed mass

Microscopic (histologic) description
  • Abundant, bizarre appearing tumor giant cells, many multinucleated; smaller fusiform cells, extensive necrosis, brisk mitotic activity, abundant stromal reticulin, occasional perivascular lymphocyte cuffing
Microscopic (histologic) images

Case #292
H&E and GFAP H&E and GFAP H&E and GFAP H&E and GFAP


H&E and GFAP H&E and GFAP H&E and GFAP H&E and GFAP

H&E and GFAP

Positive stains
Negative stains
  • Neuronal markers
Molecular / cytogenetics description
  • p53 mutations in 75 - 90%, PTEN mutations in 1/3; EGFR amplification is rare
Differential diagnosis
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