CNS & pituitary tumors

Other tumors

Solitary fibrous tumor

Last author update: 1 August 2014
Last staff update: 27 January 2023 (update in progress)

Copyright: 2002-2023,, Inc.

PubMed Search: Hemangiopericytoma CNS

Jesse L. Kresak, M.D.
Anthony T. Yachnis, M.D.
Page views in 2022: 6,088
Page views in 2023 to date: 1,390
Cite this page: Kresak JL, Yachnis AT. Solitary fibrous tumor. website. Accessed March 28th, 2023.
Definition / general
  • Grade II or III of IV
    • Most are grade II
    • Criteria for grade III include > 5 mitoses/10 HPF with "moderate to high" nuclear atypia and "moderate to high" cellularity
  • < 1% of all primary CNS tumors
  • 60% men, mean age 45 years
  • Usually single mass attached to meninges of brain or spinal cord (resembles meningioma radiographically)
  • Recently reported overall survival (OS) 84 months, 5 year survival 94% and 10 year survival 72%, (World Neurosurg 2014;81:556)
  • 41% recur, 12 - 20% metastasize to extra or intracranial sites (World Neurosurg 2014;81:556)
  • May invade through neighboring bone
  • Hemangiopericytoma is still current terminology in the CNS and is a distinct neuropathologic entity (not lumped together with solitary fibrous tumor)
  • Formerly called angioblastic meningioma
  • Dural based
  • Often supratentorial
  • 10% spinal
Radiology description
  • Often homogenously enhancing and well demarcated from adjacent brain - resembles meningioma
Radiology images

Images hosted on other servers:

Vividly enhancing mass, various images

Extra-axial mass, various images

Tumor mass in the left cerebellum

Resection cavity with residual tumor tissue

Prognostic factors
  • Grade III associated with worse overall survival
  • No statistical significance between grades II and III in regards to metastatic potential or local recurrence (J Clin Neurosci 2014;21:1310)
Case reports
Gross description
  • Dural based, gray to red
  • May be well circumscribed from brain parenchyma
  • Size can vary widely
Microscopic (histologic) description
  • Sheets of cells with uniform hypercellularity, cells are homogeneous with moderate amount of cytoplasm, round to oval nuclei and moderate pleomorphism
  • Monomorphous cellular spindle cell tumor with round to oval nuclei
  • Intratumoral staghorn vessels
  • May have storiform pattern
Cytology description
  • Cohesive clusters, does not squash well
  • Individual cells, when present, are round to ovoid "naked nuclei"
Cytology images

Images hosted on other servers:

Squash prep, low power

Squash prep, higher power

Positive stains
Negative stains
Electron microscopy description
  • Extensive basement membrane around every cell
  • Small bundles of intermediate filaments
  • No desmosomes
  • No gap junctions
Differential diagnosis
Additional references
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