CNS & pituitary tumors

Pineal tumors


Last author update: 1 January 2006
Last staff update: 9 August 2023

Copyright: 2002-2024,, Inc.

PubMed Search: Pineocytoma [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Pineocytoma. website. Accessed April 15th, 2024.
Definition / general
  • Grade 1 of 4
  • Mostly adults age 25 - 35 years
  • Slow growing
  • Average survival 7 years
Gross description
  • Well circumscribed, gray, hemorrhagic
Microscopic (histologic) description
  • Similar to normal pineal glands well differentiated cells but hypercellular
  • Fibrovascular stroma highlights expansive lobules of tumor cells with uniform round nuclei
  • Pinocytomatous rosettes (large, loose, Homer Wright-like rosettes with central fibrillar zones surrounded by neoplastic cells with round nuclei)
  • May have features of neuronal differentiation (ganglion cells)
  • Noninfiltrative, no / rare mitotic figures, no necrosis, no / minimal atypia
Differential diagnosis
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