CNS tumor

Pineal tumors


Topic Completed: 1 January 2006

Minor changes: 18 August 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Pineocytoma [title]

Nat Pernick, M.D.
Page views in 2020: 2,448
Page views in 2021 to date: 3,088
Cite this page: Pernick N. Pineocytoma. website. Accessed December 6th, 2021.
Definition / general
  • Grade I of IV
  • Mostly adults age 25 - 35 years
  • Slow growing
  • Average survival 7 years
Gross description
  • Well circumscribed, gray, hemorrhagic
Microscopic (histologic) description
  • Similar to normal pineal glands well differentiated cells but hypercellular
  • Fibrovascular stroma highlights expansive lobules of tumor cells with uniform round nuclei
  • Pinocytomatous rosettes (large, loose, Homer Wright-like rosettes with central fibrillar zones surrounded by neoplastic cells with round nuclei)
  • May have features of neuronal differentiation (ganglion cells)
  • Noninfiltrative, no / rare mitotic figures, no necrosis, no / minimal atypia
Differential diagnosis
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