CNS tumor

Sellar region tumors

Pituitary carcinoma



Topic Completed: 1 January 2006

Minor changes: 29 October 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Pituitary carcinoma [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Pituitary carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumorpituitarycarcinoma.html. Accessed December 8th, 2021.
Definition / general
  • 0.2 to 0.5% of adenohypophyseal tumors
  • Considered to derive from pituitary adenoma
  • Defined as tumors that have metastasized, since cannot differentiate based on histology (like other endocrine tumors)
  • Usually secrete ACTH or prolactin
  • "Silent" pituitary tumors rarely metastasize
  • Highly aggressive, eventually causing death
Case reports
Microscopic (histologic) description
  • May have nuclear pleomorphism with prominent nucleoli, mitotic activity
Positive stains
  • May have high Ki67 labeling index
  • p53
Differential diagnosis
Additional references
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