CNS tumor

Sellar region tumors

Pituitary carcinoma

Topic Completed: 1 January 2006

Minor changes: 29 October 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Pituitary carcinoma [title]

Nat Pernick, M.D.
Page views in 2020: 1,983
Page views in 2021 to date: 2,433
Cite this page: Pernick N. Pituitary carcinoma. website. Accessed December 8th, 2021.
Definition / general
  • 0.2 to 0.5% of adenohypophyseal tumors
  • Considered to derive from pituitary adenoma
  • Defined as tumors that have metastasized, since cannot differentiate based on histology (like other endocrine tumors)
  • Usually secrete ACTH or prolactin
  • "Silent" pituitary tumors rarely metastasize
  • Highly aggressive, eventually causing death
Case reports
Microscopic (histologic) description
  • May have nuclear pleomorphism with prominent nucleoli, mitotic activity
Positive stains
  • May have high Ki67 labeling index
  • p53
Differential diagnosis
Additional references
Back to top
Image 01 Image 02