CNS tumor
Meningeal tumors
Secretory meningioma

Topic Completed: 1 April 2014

Minor changes: 12 December 2019

Revised: 2 January 2018, last major update April 2014

Copyright: (c) 2002-2017,, Inc.

PubMed Search: "Secretory meningioma"

Jesse L. Kresak, M.D.
Anthony T. Yachnis, M.D.
Page views in 2019: 2,045
Page views in 2020 to date: 1,329
Cite this page: Kresak J. Secretory meningioma. website. Accessed August 14th, 2020.
Definition / general
Radiology description
Radiology images

Images hosted on other servers:

Cystic changes

Heterogeneous strong enhancement

Axial T1 weighted

Typical "xenon light"

Peritumoral brain edema

Axial Gd-DTPA enhanced images

High resolution CT

Postcontrast T1 WI MRI

Case reports
Gross description
  • Dural based of variable size
Microscopic (histologic) description
  • Intracellular lumina with eosinophilic, granular or hyalinized secretions referred to as "pseudopsammoma bodies"
  • Secretions are PAS+ and CEA+
  • Additional areas have classic meningioma histology
  • May have abundant mast cells (Neurosurg Rev 2006;29:41)
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #325:





Images hosted on other servers:


Classic vs. secretory meningioma

Various images

Pseudo-psammoma bodies, H&E

Cells with lumina containing PAS+ inclusions

H&E and PAS



Alcian blue


Cytology description
  • Hypercellular cohesive clusters of uniformly dense cells with eosinophilic cytoplasm, smooth nuclear outlines and even chromatin
  • Also cells with syncytial arrangements, whorls and nuclear pseudoinclusions (Acta Cytol 1999;43:121)
Cytology images

Images hosted on other servers:

Various images

Positive stains
  • Secretions positive for PAS and CEA
  • Tumor cells surrounding secretions are positive for CEA and sometimes cytokeratin
  • EMA, PR
Negative stains
Electron microscopy description
  • Hyaline inclusions are intracellular and within intercellular lumina lined by microvilli; inclusions contain granular material forming a dense core
  • Also microvesicles, dense bodies and lamellar structures
Molecular / cytogenetics description
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