CNS tumor

Sellar region tumors

Spindle cell oncocytoma



Topic Completed: 1 January 2006

Minor changes: 28 July 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Spindle cell oncocytoma of adenohypophysis

Nat Pernick, M.D.
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Cite this page: Pernick N. Spindle cell oncocytoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumorspindlecelloncocytoma.html. Accessed December 8th, 2021.
Definition / general
  • First described in 2002 (Am J Surg Pathol 2002;26:1048)
  • Mean 62 years, range 53 - 71 years
  • Associated with panhypopituitarism and variable visual field defect
  • Benign; no recurrence if totally excised
  • May derive from adenohypophyseal folliculostellate cells
Radiology description
  • Suprasellar extension
  • Resembles pituitary adenoma
  • No dural involvement
Microscopic (histologic) description
  • Fascicles of spindle cells with granular and eosinophilic cytoplasm
  • No / rare mitotic figures
  • No necrosis
Positive stains
Negative stains
Electron microscopy description
  • Mitochodria rich in lamellar cristae
  • Intermediate junctions and desmosomes, rough endoplasmic reticulum
  • No secretory granules
Differential diagnosis
  • Ectopic salivary gland rests undergoing oncocytic transformation
  • Meningioma with oncocytic change: EMA+ but intrasellar extension is rare; also whorls, interdigitation of cell membrane, S100- (except in fibrous meningioma)
  • Metastatic extracranial oncocytic tumor
  • Pituitary adenoma with oncocytic change: keratin+, synpatophysin+, neurosecretory granules+; chromogranin+, S100-, vimentin-, EMA-
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