CNS & pituitary tumors
Germ cell tumors
Yolk sac tumor
Author: Nat Pernick, M.D.
Last author update: 1 January 2006
Last staff update: 27 August 2020
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Yolk sac tumor CNS
Table of Contents
Definition / general | Case reports | Gross description | Microscopic (histologic) description | Positive stains | Additional referencesCite this page: Pernick N. Yolk sac tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumoryst.html. Accessed March 30th, 2023.
Definition / general
- Rare intracranial tumor, usually in pineal or suprasellar regions
- Also called endodermal sinus tumor
- Prognosis poorer than germinoma (median survival 2 years or less)
Case reports
- 15 year old girl with an unusual presentation of an intraparenchymatous frontal yolk sac tumor (Neurol India 2001;49:395)
- 22 year old man with Down syndrome and pineal yolk sac tumor with a solid pattern (J Clin Pathol 2004;57:882)
Gross description
- Usually large
Microscopic (histologic) description
- Tubulopapillary structures with vacuolated cuboidal cells, cystic spaces with eosinophilic hyaline bodies and Schiller-Duval bodies
Positive stains
Additional references
