Coagulation laboratory tests

International sensitivity index (ISI)

Last author update: 1 November 2012
Last staff update: 22 September 2020

Copyright: 2002-2024,, Inc.

PubMed Search: International sensitivity index [title]

Jeremy C. Parsons, M.D.
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Table of Contents
Definition / general
Cite this page: Parsons JC. International sensitivity index (ISI). website. Accessed February 23rd, 2024.
Definition / general
  • Measure of sensitivity of particular PT reagent - determined by manufacturer
  • Used to resolve interlaboratory variations in PT (Arch Pathol Lab Med 2004;128:308, J Clin Pathol 2003;56:114)
  • Different PT reagents have different sensitivities to factor deficiencies
  • High ISI (3.0) means insensitive reagent vs. low ISI (1.0) means sensitive reagent
  • Labs should use reagents with an ISI of 1.0 to 1.5, if possible
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