Cite this page: Parsons JC. Acquired thrombophilia - general. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/coagulationacquiredhypercoaggeneral.html. Accessed October 18th, 2021.
Definition / general
- Thrombophilia: any disorder associated with increased risk of venous thromboembolic disease; more appropriately called "hypercoagulable state" if not genetic, although terms often used interchangeably
- Common risk factors are: antiphospholipid antibodies, chronic DIC, essential thrombocythemia, heparin induced thrombocytopenia, hyperhomocysteinemia, immobility, increasing age, malignancy, nephrotic syndrome, obesity, oral contraceptives, paroxysmal nocturnal hemoglobinuria, polycythemia vera, postoperative state, pregnancy, prior thromboembolism, systemic lupus erythematosus, trauma
- Presence of more than one risk factor further increases risk (Arch Pathol Lab Med 2002;126:295)