Table of ContentsDefinition / general | Case reports | Clinical images | Additional references
Cite this page: Parsons JC. Acquired thrombophilia - general. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/coagulationacquiredhypercoaggeneral.html. Accessed June 3rd, 2023.
Definition / general
- Thrombophilia: any disorder associated with increased risk of venous thromboembolic disease; more appropriately called "hypercoagulable state" if not genetic, although terms often used interchangeably
- Common risk factors are: antiphospholipid antibodies, chronic DIC, essential thrombocythemia, heparin induced thrombocytopenia, hyperhomocysteinemia, immobility, increasing age, malignancy, nephrotic syndrome, obesity, oral contraceptives, paroxysmal nocturnal hemoglobinuria, polycythemia vera, postoperative state, pregnancy, prior thromboembolism, systemic lupus erythematosus, trauma
- Presence of more than one risk factor further increases risk (Arch Pathol Lab Med 2002;126:295)
- 33 year old man with fatal pulmonary emboli associated with hypereosinophilia (J Clin Path 2004;57:541)
- 52 year old woman with portal vein thrombosis associated with myeloproliferative disorder (Arch Pathol Lab Med 2003;127:e385)