Acquired thrombophilia / hypercoagulopathies
Acquired thrombophilia - general

Topic Completed: 1 April 2013

Revised: 7 January 2019, last major update April 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Acquired thrombophilia [title]

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Cite this page: Parsons J. Acquired thrombophilia - general. website. Accessed August 3rd, 2020.
Definition / general
  • Thrombophilia: any disorder associated with increased risk of venous thromboembolic disease; more appropriately called "hypercoagulable state" if not genetic, although terms often used interchangeably
  • Common risk factors are: antiphospholipid antibodies, chronic DIC, essential thrombocythemia, heparin induced thrombocytopenia, hyperhomocysteinemia, immobility, increasing age, malignancy, nephrotic syndrome, obesity, oral contraceptives, paroxysmal nocturnal hemoglobinuria, polycythemia vera, postoperative state, pregnancy, prior thromboembolism, systemic lupus erythematosus, trauma
  • Presence of more than one risk factor further increases risk (Arch Pathol Lab Med 2002;126:295)
Diagrams / tables

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Initiation and propagation of blood coagulation

Activation of protein C by thrombin-thrombomodulin

Degradation of FVa and FVIIIa by APC

Blood coagulation
and protein C

Activation and degradation of normal FV and FV Leiden

20210G > A mutation in the prothrombin gene

Regulation of hemostasis

Balance of hemostasis

of various
procoagulant proteins

Activated protein C (APC)

Transsulfuration pathway and metabolism of homocysteine

Case reports
Clinical images

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Thrombi in major
trunks of pulmonary
artery and large thrombus
near left iliac vein.

Microscopic (histologic) images

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Fig. 1 / 2: old, recanalized thrombi in portal veins;
fig. 3: recanalization of portal vein webs with intimal tags;
fig. 4: bone marrow is hypercellular with large, dysplastic, abnormally clustered megakaryocytes

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