Cite this page: Parsons J. Antithrombin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/coagulationantithrombinnormal.html. Accessed August 3rd, 2020.
Definition / general
- Formerly called antithrombin III
- Member of serine protease inhibitor (serpin) gene family on #1q23-25
- Functions as anticoagulant by inhibiting activated factors II (thrombin), IX, X, XI, XII, kallikrein, plasmin and probably factor VII (all are serine proteases)
- Activity is accelerated 1000x by interaction with heparin or heparan sulfate (located on endothelial cells)