Acquired bleeding disorders

Bovine coagulation factor inhibitors

Last author update: 1 August 2010
Last staff update: 14 September 2020

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PubMed Search: Bovine coagulation factor inhibitors [title]

Kendall Crookston, M.D., Ph.D.
Julie Kim Harrington, M.D.
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Cite this page: Crookston K, Rosenbaum LS, Gober-Wilcox J. Bovine coagulation factor inhibitors. website. Accessed May 18th, 2022.
Definition / general
  • Antibodies that develop against bovine proteins after exposure to topical bovine thrombin preparations which can potentially cross-react with corresponding human coagulation factors
  • Antibodies can form against bovine thrombin, factor V/Va, and fibrinogen, and less commonly against bovine factors VII and X
  • Some fibrin glues contain bovine thrombin and cryoprecipitate (containing human fibrinogen)
  • After use of bovine "fibrin glue" to achieve hemostasis, 1.7% develop a clinically significant inhibitor
  • Prolonged PT and PTT that does not correct with mixing studies
Case reports
  • Steroids, cyclophosphamide, cyclosporine A, IV immunoglobulin
  • Management of acute bleeding includes plasmapheresis, platelet-transfusions and immunoabsorption
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