Coagulation laboratory tests

Hypercoagulation panel

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Last staff update: 22 September 2020

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PubMed Search: Hypercoagulation panel

Jeremy C. Parsons, M.D.
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Table of Contents
Definition / general
Cite this page: Parsons JC. Hypercoagulation panel. website. Accessed June 2nd, 2023.
Definition / general
  • Panels are useful to identify all factors predisposing to thrombosis; vary by institution
  • Laboratory must be notified if patient is receiving therapeutic anticoagulants (heparin, warfarin, danaparoid, hirudin, argatroban)
  • Venous thrombosis panel typically includes assays for activated protein C resistance (factor V Leiden), protein C, protein S, antithrombin, prothrombin G20210A mutation assay, antiphospholipid antibodies and homocysteine
  • Less common are assays for plasminogen, dysfibrinogenemia (e.g. reptilase time), heparin cofactor II or platelet hyperaggregability
  • Arterial thrombosis panel may include antiphospholipid antibodies, homocysteine levels, lipoprotein (a) (if arterial thrombosis occurs with coronary artery disease, myocardial infarction or stroke)
  • In special circumstances, arterial thrombosis may be due to thrombotic diatheses tested on the venous thrombosis panel

  • Note: clinicians often confuse Factor V Leiden (to workup thrombosis) with Factor V assay (not the correct test); prevent with use of hypercoagulation panel
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