Coagulation
Coagulation laboratory tests
Hypercoagulation panel
Author: Jeremy C. Parsons, M.D.
Last author update: 1 November 2012
Last staff update: 22 September 2020
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Hypercoagulation panel
Table of Contents
Definition / generalCite this page: Parsons JC. Hypercoagulation panel. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/coagulationhypercoagulationpanel.html. Accessed June 2nd, 2023.
Definition / general
- Panels are useful to identify all factors predisposing to thrombosis; vary by institution
- Laboratory must be notified if patient is receiving therapeutic anticoagulants (heparin, warfarin, danaparoid, hirudin, argatroban)
- Venous thrombosis panel typically includes assays for activated protein C resistance (factor V Leiden), protein C, protein S, antithrombin, prothrombin G20210A mutation assay, antiphospholipid antibodies and homocysteine
- Less common are assays for plasminogen, dysfibrinogenemia (e.g. reptilase time), heparin cofactor II or platelet hyperaggregability
- Arterial thrombosis panel may include antiphospholipid antibodies, homocysteine levels, lipoprotein (a) (if arterial thrombosis occurs with coronary artery disease, myocardial infarction or stroke)
- In special circumstances, arterial thrombosis may be due to thrombotic diatheses tested on the venous thrombosis panel
- Note: clinicians often confuse Factor V Leiden (to workup thrombosis) with Factor V assay (not the correct test); prevent with use of hypercoagulation panel
