Coagulation

Coagulation laboratory tests

Platelet hyperaggregation studies



Topic Completed: 1 November 2012

Minor changes: 23 February 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Platelet hyperaggregation studies

Jeremy C. Parsons, M.D.
Page views in 2020: 403
Page views in 2021 to date: 311
Cite this page: Parsons JC. Platelet hyperaggregation studies. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/coagulationplatelethyperaggregationstudies.html. Accessed October 18th, 2021.
Definition / general
  • Hyperaggregation may rarely be associated with hypercoagulability, including myocardial infarction, strokes and venous thrombosis
  • Tested patients should have abstained from aspirin, NSAIDs or platelet-inhibiting drugs for 7 days prior to testing

  • Indications: patients with unexplained hypercoagulability and normal values in hypercoagulation panel
Laboratory
  • Similar to platelet aggregation
  • Centrifuge citrated plasma gently to draw red and white blood cells into a pellet, which leaves platelets suspended in the plasma
  • Then add various agonists at multiple low concentrations and a control (no agonist, to measure spontaneous aggregation), and measure platelet aggregation with an aggregometer (which measures optical density)
  • Must carefully evaluate patient's use of medications (including over the counter)
  • Must compare to normal control, and results can be subjective
Back to top
Image 01 Image 02