Coagulation laboratory tests
Reptilase time

Topic Completed: 1 November 2012

Revised: 7 January 2019, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Reptilase time [title]

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Table of Contents
Definition / general
Cite this page: Parsons J. Reptilase time. website. Accessed May 29th, 2020.
Definition / general
  • Clotting time similar to thrombin time, but uses snake venom (reptilase) instead of thrombin
  • Measure rate of fibrin clot formation after addition of reptilase to citrated plasma
  • Generates a fibrin clot by cleaving fibrinopeptide A from fibrinogen
  • Prolonged by decreased or dysfunctional fibrinogen, or high levels of fibrin degradation products; also amyloidosis (inhibits fibrinogen conversion to fibrin); also prolonged by increased fibrinogen associated with acute phase reaction (Am J Clin Pathol 2002;118:263)
  • Used to diagnose dysfibrinogenemia (also thrombin time)
  • Not prolonged by heparin or hirudin (unlike thrombin time)
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