Coagulation laboratory tests

Reptilase time

Last author update: 1 November 2012
Last staff update: 23 September 2020

Copyright: 2002-2024,, Inc.

PubMed Search: Reptilase time [title]

Jeremy C. Parsons, M.D.
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Table of Contents
Definition / general
Cite this page: Parsons JC. Reptilase time. website. Accessed February 23rd, 2024.
Definition / general
  • Clotting time similar to thrombin time, but uses snake venom (reptilase) instead of thrombin
  • Measure rate of fibrin clot formation after addition of reptilase to citrated plasma
  • Generates a fibrin clot by cleaving fibrinopeptide A from fibrinogen
  • Prolonged by decreased or dysfunctional fibrinogen, or high levels of fibrin degradation products; also amyloidosis (inhibits fibrinogen conversion to fibrin); also prolonged by increased fibrinogen associated with acute phase reaction (Am J Clin Pathol 2002;118:263)
  • Used to diagnose dysfibrinogenemia (also thrombin time)
  • Not prolonged by heparin or hirudin (unlike thrombin time)
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