Coagulation
Hereditary thrombophilia / hypercoagulopathies
Sickle cell disease



Topic Completed: 1 June 2012

Revised: 7 January 2019, last major update June 2012

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PubMed Search: Sickle cell disease [title]


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Cite this page: Parsons J. Sickle cell disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/coagulationsicklecelldisease.html. Accessed May 29th, 2020.
Definition / general
  • Associated with increases in thrombin generation, fibrinolytic activation, platelet activation, increased antiphospholipid antibodies, decreased levels of circulating anticoagulants and contact factors
  • Also increased circulating levels of tissue factor and endothelial cells expressing a tissue factor phenotype
  • Have hypercoagulable state based on thermoelastographic profiles (Arch Pathol Lab Med 2005;129:760)
Additional references
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