Colon non tumor
Nonneoplastic, noncongenital lesions
Barium granuloma

Topic Completed: 1 August 2013

Revised: 9 January 2019, last major update August 2013

Copyright: (c) 2003-2017,, Inc.

PubMed Search: barium granuloma

Raul S. Gonzalez, M.D.
Page views in 2019: 262
Page views in 2020 to date: 122
Cite this page: Gonzalez R. Barium granuloma. website. Accessed May 27th, 2020.
Definition / general
  • Reactive response to barium sulfate implantation underneath colonic mucosa
  • Rare
  • Can occur anywhere in colon
  • May occur after barium enema if barium penetrates mucosal tear and stimulates a granulomatous reaction
Clinical features
  • Usually an incidental finding; may occur in preexisting ulcerated lesions that were evaluated by barium enema; rarely produces polypoid or ulcerated lesion resembling a neoplasm (Dis Colon Rectum 1981;24:388)
  • Electron microscopy can confirm that foreign material is barium
Case reports
Gross description
Microscopic (histologic) description
  • Barium is green, crystalline and refractile; crystals occur in clusters in macrophages or connective tissue and can be observed under polarized light
Microscopic (histologic) images

Images hosted on other servers:

Low power

High power

Refractile particulate material (Fig 1b)

Additional references
Back to top