Other nonneoplastic

Elastofibromatous change

Topic Completed: 15 April 2021

Minor changes: 21 April 2021

Copyright: 2003-2021,, Inc.

PubMed Search: elastofibromatous

Raul S. Gonzalez, M.D.
Page views in 2020: 1,044
Page views in 2021 to date: 1,269
Cite this page: Gonzalez RS. Elastofibromatous change. website. Accessed October 28th, 2021.
Definition / general
  • Increase in elastin fibers in colonic submucosa
Essential features
  • Uncommon collection of amorphous elastotic material in colon
  • Seemingly no clinical significance but can mimic amyloid
  • Also called elastosis
  • Called elastofibroma if forms a polyp
  • Occurs throughout gastrointestinal tract
  • In colon, favors left side; can present in rectum
Clinical features
  • Patients typically older than 45
  • No sex predilection
  • May cause nonspecific gastrointestinal symptoms or be asymptomatic
Case reports
Gross description
  • May appear as a polyp or as a linear white lesion
Microscopic (histologic) description
  • Eosinophilic to gray amorphous material, sometimes with fibrous tissue, involving submocusa or muscularis mucosae
  • May be centered around blood vessels (Am J Clin Pathol 2004;122:232)
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.

Submucosal elastofibromatous change mimicking amyloid

Elastin stain

Positive stains
Negative stains
Sample pathology report
  • Descending colon, polypectomy:
    • Colon with elastofibromatous change (see comment)
    • Comment: The polyp consists of submucosal amorphous material that is negative on a Congo red special stain and positive on an elastin special stain.
Differential diagnosis
Board review style question #1

    The material seen in the photo was seen in a colon polyp. It stained positive with an elastin stain. What is the best diagnosis?

  1. Amyloid
  2. Elastofibromatous change
  3. Lifting agent material
  4. Pulse granuloma
Board review style answer #1
B. Elastofibromatous change

Comment Here

Reference: Elastofibromatous change
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