Other nonneoplastic

Gastric heterotopia

Topic Completed: 24 February 2021

Minor changes: 5 March 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Gastric heterotopia colon

Raul S. Gonzalez, M.D.
Page views in 2020: 1,156
Page views in 2021 to date: 1,043
Cite this page: Gonzalez RS. Gastric heterotopia. website. Accessed October 21st, 2021.
Definition / general
  • Gastric tissue aberrantly present in colon
  • See also heterotopia topic
Essential features
  • Rare finding that usually consists of oxyntic type gastric tissue
  • Helicobacter pylori organisms may be present
  • < 50 cases reported
Clinical features
  • Mean age 18 years but wide range
  • Slight male predominance
  • Associated with other heterotopias, with vertebral and digital anomalies
  • In rectum, usually presents with rectal bleeding and tenesmus (J Clin Gastroenterol 1994;19:41)
  • At colonoscopy, may appear as polyp, ulcer or diverticulum
Case reports
  • Excision, H2 blockers
Microscopic (histologic) description
  • Gastric tissue (typically oxyntic type but may be pyloric type) in colon
  • Helicobacter pylori organisms may be present
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.
Gastric heterotopia

Gastric heterotopia

Images hosted on other servers:

Gastric and colonic mucosa

Gastric and colonic mucosa

Heterotopic gastric mucosa with cystic dilatation

Sample pathology report
  • Rectum, mass, biopsy:
    • Gastric heterotopia (see comment)
    • Comment: Helicobacter organisms are not identified by immunohistochemistry.
Board review style question #1

Which of the following is true about gastric heterotopia in the colorectum?

  1. It can harbor Helicobacter pylori
  2. It is commonly observed endoscopically but rarely biopsied
  3. It is usually pyloric type rather than oxyntic type
  4. It often progresses to malignancy
Board review style answer #1
A. It can harbor Helicobacter pylori

Comment Here

Reference: Gastric heterotopia
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