Colon
Noninfectious colitis
Malakoplakia
Author: Hanni Gulwani, M.B.B.S.
Last author update: 1 March 2015
Last staff update: 30 September 2020
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: malakoplakia [title] colon
Table of Contents
Definition / general | Case reports | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Virtual slidesCite this page: Gulwani H. Malakoplakia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/colonmalakoplakia.html. Accessed April 19th, 2024.
Definition / general
- Marked histiocytic infiltrate, more common in bladder, that may diffusely involve colon
- Usually adults, associated with immunosuppression
- Due to defective inflammatory response to gram negative bacterial infection
- Rarely associated with colorectal carcinoma in elderly men (Pathology 2002;34:332)
Case reports
- 2 cases of pediatric malakoplakia of colon (Pediatr Surg Int 2010;26:323)
- 4 year old boy with coexisting celiac disease and chronic granulomatous disease (Indian J Gastroenterol 2006;25:163)
- 54 year old man with liver transplant (Arch Pathol Lab Med 2004;128:e133)
- 58 year old woman with liver transplant (Can J Gastroenterol 2007;21:753)
- 64 year old man with colonic adenocarcinoma (World J Gastroenterol 2007;13:6109)
- 74 year old man with malakoplakia adjacent to adenocarcinoma (J Clin Pathol 1993;46:959)
Gross description
- Diffuse mucosal involvement and submucosal thickening; may cause mass
Microscopic (histologic) description
- Marked histiocytic infiltrate containing Michaelis-Gutmann bodies (calcospherites) that may resemble signet ring cells at frozen section
Microscopic (histologic) images
Images hosted on other servers:
Michaelis-Gutmann bodies
Liver transplant recipient
Adjacent to adenocarcinoma
Virtual slides
Images hosted on other servers:
Large bowel
