Noninfectious colitis

NSAID associated colitis

Topic Completed: 1 May 2013

Minor changes: 30 September 2020

Copyright: 2003-2021,, Inc.

PubMed Search: NSAID associated colitis

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. NSAID associated colitis. website. Accessed October 25th, 2021.
Definition / general
  • Associated with bleeding, diarrhea, abdominal pain, although usual side effects are subclinical (Am J Med Sci 2009;338:96)
Clinical features
Case reports
Microscopic (histologic) description
  • Usually mixed inflammatory infiltrate but may be predominantly neutrophilic or lymphocytic (Am J Clin Pathol 1998;110:622, Adv Anat Pathol 1999;6:213)
  • Often erosions, crypt architectural disarray; no granulomas
  • Incidental chronic colitis: cecal based chronic colitis associated with frequent NSAID use; basal plasmacytosis (94%) or crypt architectural distortion (94%) often disappears after NSAID withdrawal (Am J Surg Pathol 2010;34:463)
Microscopic (histologic) images

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Ulcer post-NSAID therapy

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