Adenosquamous carcinoma

Last author update: 14 April 2021
Last staff update: 21 April 2021

Copyright: 2002-2024,, Inc.

PubMed Search: Adenosquamous carcinoma [title] colon

Raul S. Gonzalez, M.D.
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Cite this page: Gonzalez RS. Adenosquamous carcinoma. website. Accessed May 19th, 2024.
Definition / general
  • Rare (0.1% of colonic carcinomas) WHO recognized epithelial malignancy of colon with glandular and squamous elements (Am J Surg Pathol 1978;2:47)
Essential features
Clinical features
Case reports
  • Surgery with adjuvant treatment
Clinical images

Images hosted on other servers:

Circumferential obstructive mass

Bleeding circumferential lobulated mass

Gross images

Images hosted on other servers:

Cross section

Microscopic (histologic) description
  • Resembles conventional colorectal adenocarcinoma but with areas of squamous differentiation, either admixed or distinct
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.

Adenosquamous carcinoma

Images hosted on other servers:

Collision-like areas

Composite-like areas

Adenosquamous carcinoma

Malignant squamous cells with keratinization

Sample pathology report
  • Ascending colon, biopsy:
    • Adenosquamous carcinoma (see comment)
    • Comment: The malignancy demonstrates both glandular elements and squamous elements. The former is positive for CDX2 by immunohistochemistry and the latter is positive for p40 by immunohistochemistry.
Differential diagnosis
Board review style question #1

Which of the following is true about adenosquamous carcinoma of the colon?

  1. Always arises in the setting of HPV infection
  2. Has a good prognosis
  3. Often presents at an advanced stage
  4. Represents approximately 10% of colorectal carcinomas
Board review style answer #1
C. Often presents at an advanced stage

Comment Here

Reference: Adenosquamous carcinoma
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