Colon tumor
Biopsies of colon

Topic Completed: 1 May 2012

Minor changes: 10 June 2019

Copyright: 2003-2019,, Inc.

PubMed Search: biopsies[title] colon

Shilpa Jain, M.D.
Page views in 2019: 911
Page views in 2020 to date: 311
Table of Contents
Definition / general
Cite this page: Jain S. Biopsies of colon. website. Accessed May 27th, 2020.
Definition / general
  • Recommended to submit entire biopsy material and cut 3 levels
  • If clinically is a polyp but microscopically is normal, flipping specimen after melting paraffin block gives definitive diagnosis in 30% of cases (Am J Surg Pathol 2003;27:254)
  • Deeper levels may reveal polyps in negative biopsies (Am J Clin Pathol 2002;117:424)
  • Difficult to diagnose carcinoma (i.e. invasion into submucosa) if no submucosa is present
  • Can diagnose invasion if (a) marked desmoplasia, (b) infiltrative pattern, (c) ulceration or (d) clinical mass lesion
  • Muciphages, without other abnormalities, have no clinical significance (Histopathology 2000;36:556)
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